C1-Esterase Inhibitor Level
Clinical Background:
C1 esterase inhibitor is an enzyme which controls activation of the classical complement pathway alongwith inhibition of enzymes in the blood clotting pathway. Genetic deficiencies exist which cau...
C1 esterase inhibitor is an enzyme which controls activation of the classical complement pathway alongwith inhibition of enzymes in the blood clotting pathway. Genetic deficiencies exist which cause Hereditary Angioedema (HAE). The majority of patients have low levels of C1 esterase inhibitor, with around 20% of patients having normal levels of a non functional inhibitor.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
1 ml
1 ml
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Minimum Volume Paediatric:
1 ml
1 ml
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Special Requirement:
Samples MUST be separated within 4 hours of venesection. Please ensure that the sample arrives in the laboratory as soon as possible after being taken.
Samples MUST be separated within 4 hours of venesection. Please ensure that the sample arrives in the laboratory as soon as possible after being taken.
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Freq Analysis:
Fortnightly
Fortnightly
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Add On Test:
Cannot be added on without discussion with Proteins Laboratory
Cannot be added on without discussion with Proteins Laboratory
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Quality Assurance:
UK NEQAS for C1 Inhibitor and Functional Complement
INSTAND Complement EQA scheme
UK NEQAS for C1 Inhibitor and Functional Complement
INSTAND Complement EQA scheme
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Interpretation:
Low levels are associated with Type I HAE. Normal C1 esterase levels does not rule out HAE and so C1 functional testing is carried out to rule out a problem with enzyme function.
Low levels are associated with Type I HAE. Normal C1 esterase levels does not rule out HAE and so C1 functional testing is carried out to rule out a problem with enzyme function.
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Reference Ranges:
Normal Adult Range: >0.18 mg/L
Normal Adult Range: >0.18 mg/L
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Other Info:
Reported as a numerical value
Reported as a numerical value
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Routine Contact Name:
Proteins Lab
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Routine Telephone:
0191 282 4766
0191 282 4766
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Routine Email: