C1-Esterase Inhibitor Function
Clinical Background:
This should be measured in cases of angioedema with low C4, when the total immunochemical C1-esterase inhibitor level is normal or high.
This should be measured in cases of angioedema with low C4, when the total immunochemical C1-esterase inhibitor level is normal or high.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
2 ml
2 ml
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Minimum Volume Paediatric:
2 ml
2 ml
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Special Requirement:
Samples MUST be separated within 4 hours of venesection. Please ensure that the sample arrives in the laboratory as soon as possible after being taken.
Samples MUST be separated within 4 hours of venesection. Please ensure that the sample arrives in the laboratory as soon as possible after being taken.
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Sample Stability:
Stored for 1 year at -80 degrees. Samples should not be freeze thawed prior to testing
Stored for 1 year at -80 degrees. Samples should not be freeze thawed prior to testing
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Freq Analysis:
Fortnightly
Fortnightly
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Add On Test:
Cannot be added on due to stability issues. Please discuss with the Protein Laboratory
Cannot be added on due to stability issues. Please discuss with the Protein Laboratory
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Quality Assurance:
UK NEQAS for C1 Inhibitor and Functional Complement
INSTAND Complement EQA scheme
UK NEQAS for C1 Inhibitor and Functional Complement
INSTAND Complement EQA scheme
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Interpretation:
Low levels are associated with HAE. However due to stability of C1 esterase inhibitor low levels should be discussed with Immunology
Low levels are associated with HAE. However due to stability of C1 esterase inhibitor low levels should be discussed with Immunology
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Reference Ranges:
Normal Adult Range: 70-130% [expressed as % activity when compared to the control serum]
Normal Adult Range: 70-130% [expressed as % activity when compared to the control serum]
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Other Info:
Reported as a % of the activity of the control serum used in the assay.
Reported as a % of the activity of the control serum used in the assay.
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Routine Contact Name:
Proteins Lab
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Routine Telephone:
0191 282 4766
0191 282 4766
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Routine Email: