Beta interferon neutralising antibodies
Clinical Background:
Interferon-beta (IFNβ) is a first-line therapy for relapsing remitting multiple sclerosis (MS). However, some patients develop binding antibodies (BAbs) and neutralising antibodies (NAbs) during th...
Interferon-beta (IFNβ) is a first-line therapy for relapsing remitting multiple sclerosis (MS). However, some patients develop binding antibodies (BAbs) and neutralising antibodies (NAbs) during their treatment with recombinant IFNβ products. Clinical studies have demonstrated that high levels of Nabs to IFNβ will reduce or abolish the therapeutic benefits.
The measurement of Nabs to IFNβ in the serum of MS patients on treatment will inform the clinician as to the likely efficacy of the current therapy.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum
Serum
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Specimen Container Paediatric:
Serum
Serum
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Minimum Volume Adult:
0.5 - 1 mL
0.5 - 1 mL
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Minimum Volume Paediatric:
0.5 - 1 mL
0.5 - 1 mL
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Special Requirement:
Serum samples may be stored at 2-8oC for short periods (1 week) or frozen at -20oC for longer storage times.
Serum samples may be stored at 2-8oC for short periods (1 week) or frozen at -20oC for longer storage times.
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Transport Requirements:
First class post
First class post
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Add On Test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to
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Reference Ranges:
A NAb titre of <20 is negative. Titres of 20-100, 100-600 and >600 are classified as low, moderate and high positive.
A low level of NAbs is not thought to be sufficient to reduce the effect of IFN...
Read MoreA NAb titre of <20 is negative. Titres of 20-100, 100-600 and >600 are classified as low, moderate and high positive.
A low level of NAbs is not thought to be sufficient to reduce the effect of IFNβ treatment, whereas a high titre of NAbs is likely to abrogate the effect of IFNβ
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: