Newcastle Laboratories

Beta Crosslaps

Clinical Background:

Human bone is continuously remodelled through a process of bone formation and resorption.
Approximately 90% of the organic matrix of bone is type I collagen, a helical protein that is crosslinked ...

Human bone is continuously remodelled through a process of bone formation and resorption.
Approximately 90% of the organic matrix of bone is type I collagen, a helical protein that is crosslinked at the N- and C-terminal ends of the molecule.
During bone resorption, osteoclasts degrade the collagen fibrils into molecular fragments including C-terminal telopeptide (CTx). Beta-CTx is released into the bloodstream during bone resorption and serves as a specific marker for the degradation of mature type I collagen.


Many diseases, in particular hyperthyroidism, all forms of hyperparathyroidism, most forms of osteomalacia and rickets, hypercalcemia of malignancy, Pagets disease, multiple myeloma, and bone metastases, as well as various congenital diseases of bone formation and remodelling, can result in accelerated and unbalanced bone turnover. Unbalanced bone turnover is also found in age-related and postmenopausal osteopenia and osteoporosis. Disease-associated bone turnover abnormalities should normalize in response to effective therapeutic interventions, which can be monitored by measurement of serum bone resorption markers.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    EDTA plasma

    EDTA plasma

  • Specimen Container Paediatric:

    EDTA plasma

    EDTA plasma

  • Minimum Volume Adult:

    1ml

    1ml

  • Minimum Volume Paediatric:

    1ml

    1ml

  • Special Requirement:

    Fasting sample is preferred

    Fasting sample is preferred

  • Sample Stability:

    Before separation: 2 days

    After separation:       

    +20° to +25°C     24 hours
    +2° to +8°C          8 days
    -15° to -25°C       3 months

    ...

    Before separation: 2 days

    After separation:       

    +20° to +25°C     24 hours
    +2° to +8°C          8 days
    -15° to -25°C       3 months

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  • Reference Ranges:

    Males:

    Age 30 years – 50 years: <0.58 ug/L

    Age 51 years – 70 years: <0.70 ug/L

    Age 71 years and over: <0.85 ug/L

     

    Females:

    Premenopausal: <0.57 ug/L

    Postmenopausal <1.01 ug/L

     

    Interpretation:

    Nor...

    Males:

    Age 30 years – 50 years: <0.58 ug/L

    Age 51 years – 70 years: <0.70 ug/L

    Age 71 years and over: <0.85 ug/L

     

    Females:

    Premenopausal: <0.57 ug/L

    Postmenopausal <1.01 ug/L

     

    Interpretation:

    Normal level suggests no excessive bone turnover

    Elevated levels may be seen in conditions such as osteoporosis, hyperparathyroidism, Paget's disease of bone, osteomalacia, metastatic bone disease, untreated thyrotoxicosis, myeloma, Cushing's syndrome or high doses of glucocorticoids.

    When used to monitor anti-resorptive therapy, decreasing levels over time reflect a response to therapy.

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  • Routine Contact Name:

    Duty biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

    Freeman: 0191 244 8889

    RVI: 0191 282 9719

  • Routine Email:

Availability:

Assayed once per week, analysed at RVI

Turn Around:

8 days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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