Basal ganglia antibodies
Clinical Background:
Anti-basal ganglia antibodies (ABGA) have been associated with movement disorders and psychiatric disturbances in children. These include: Sydenham’s chorea (prototype); tics (PANDAS) and a subset ...
Anti-basal ganglia antibodies (ABGA) have been associated with movement disorders and psychiatric disturbances in children. These include: Sydenham’s chorea (prototype); tics (PANDAS) and a subset of cases with Tourette’s syndrome (TS).
ABGA may also be detected, on rare occasions, in patients with adult-onset tics, dystonia and in some cases with post-encephalitic Parkinsonism or encephalitis lethargica (EL) Anti-NMDA receptor antibodies have also been associated with EL.
A small number of patients with complex cerebellar disease of unknown aetiology also have ABGA.
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum
Serum
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Specimen Container Paediatric:
Serum
Serum
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Minimum Volume Adult:
1 mL
1 mL
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Minimum Volume Paediatric:
1 mL
1 mL
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Special Requirement:
Centrifuge sample and separate the serum within 2 hours
Centrifuge sample and separate the serum within 2 hours
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Sample Stability:
Serum samples may be stored at 2-8oC for short periods (1 week) or frozen at -20oC for longer storage times
Serum samples may be stored at 2-8oC for short periods (1 week) or frozen at -20oC for longer storage times
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Transport Requirements:
First class post
First class post
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Add On Test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: