Apolipoprotein B, serum
Clinical Background:
Apo B is important in lipoprotein transport, being essential for the secretion of triglyceride-rich lipoproteins from the liver and gut. One molecule of apo B is present in each chylomicron, VLDL o...
Apo B is important in lipoprotein transport, being essential for the secretion of triglyceride-rich lipoproteins from the liver and gut. One molecule of apo B is present in each chylomicron, VLDL or LDL particle. There are two forms of apo B - apoB100 and apoB48. ApoB48 is secreted by enterocytes and is the major protein constituent of chylomicrons. ApoB100 is the major component of all lipoproteins except chylomicrons and HDL. The majority of circulating apoB100 is found in LDL. ApoB100 is the ligand for the LDL receptor on hepatocytes and in peripheral tissues. Elevated apo B100 is a marker of increased numbers of LDL particles and a risk factor for cardiovascular disease.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
Serum
Serum
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Specimen Container Paediatric:
Serum
Serum
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Minimum Volume Adult:
1 mL blood
1 mL blood
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Minimum Volume Paediatric:
1 mL blood
1 mL blood
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Sample Stability:
Unseparated: 24 hours
Separated: 7 days at 4-8°C
Unseparated: 24 hours
Separated: 7 days at 4-8°C
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Transport Requirements:
Ambient temperature
Ambient temperature
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Interpretation:
Apo B is raised in hyperlipoproteinaemia types IIa, IIb, IV and V). Other disorders such as hepatic obstruction, renal disease, diabetes, hypothyroidism, Cushings and anorexia may lead to increased...
Read MoreApo B is raised in hyperlipoproteinaemia types IIa, IIb, IV and V). Other disorders such as hepatic obstruction, renal disease, diabetes, hypothyroidism, Cushings and anorexia may lead to increased Apo B. Decreased apo B levels are found in abetalipoproteinaemia, LCAT deficiency, hyperlipoproteinaemia type I, and lipoprotein lipase cofactor (apo CII) deficiency. Hyperthyroidism, malnutrition, malabsorption, severe hepatocellular dysfunction, Reye’s syndrome and myeloma may lead to decreased apo B concentrations.
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Reference Ranges:
Men: 0.66-1.33 g/L
Women: 0.60-1.17 g/LMen: 0.66-1.33 g/L
Women: 0.60-1.17 g/L -
Factors Affecting Result:
Gross haemolysis, icterus or lipaemia may interfere.
Gross haemolysis, icterus or lipaemia may interfere.
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Other Info:
Plasma- Lithium Heparin also acceptable
Plasma- Lithium Heparin also acceptable
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email:
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Endocrine Lab
Endocrine Lab
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Specialist Telephone:
0191 282 4025
0191 282 4025