Antithrombin III
Clinical Background:
Anti-Thrombin III, as its name suggests, is a natural anticoagulant. It is a glycoprotein produced in the liver that inactivates several enzymes of the coagulation system. Heparin exerts its antico...
Anti-Thrombin III, as its name suggests, is a natural anticoagulant. It is a glycoprotein produced in the liver that inactivates several enzymes of the coagulation system. Heparin exerts its anticoagulant activity by potentiating the action of AT-III up to 1000 fold. Deficiencies are associated with an increased risk of thrombosis and poor response to Heparin anticoagulation. This assay is part of the Thrombophilia screen
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
10.8mL
10.8mL
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Minimum Volume Paediatric:
5.2mL
5.2mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hrs
4 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
As required or weekly
As required or weekly
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Add On Test:
All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address
tnu-tr.bloodsciencesadditions@nhs.net (internal)
Read MoreAll urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address
tnu-tr.bloodsciencesadditions@nhs.net (internal)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
88 - 121%
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
88 - 121%
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
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Other Info:
Quantitative assay of antithrombin III as part of a thrombophilia screen.
Quantitative assay of antithrombin III as part of a thrombophilia screen.
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Routine Contact Name:
Special Lab Freeman
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Routine Telephone:
0191 223 1780
0191 223 1780
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Routine Email:
Joanne.hall8@nhs.net
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology/Haemostasis Health Care Scientist
Haematology/Haemostasis Health Care Scientist
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Specialist Telephone:
0191 213 9758
0191 213 9758