Newcastle Laboratories

Antithrombin III

Clinical Background:

Anti-Thrombin III, as its name suggests, is a natural anticoagulant. It is a glycoprotein produced in the liver that inactivates several enzymes of the coagulation system. Heparin exerts its antico...

Anti-Thrombin III, as its name suggests, is a natural anticoagulant. It is a glycoprotein produced in the liver that inactivates several enzymes of the coagulation system. Heparin exerts its anticoagulant activity by potentiating the action of AT-III up to 1000 fold. Deficiencies are associated with an increased risk of thrombosis and poor response to Heparin anticoagulation. This assay is part of the Thrombophilia screen

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    10.8mL

    10.8mL

  • Minimum Volume Paediatric:

    5.2mL

    5.2mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    4 hrs

    4 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    As required or weekly

    As required or weekly

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs....

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    88 - 121%

    88 - 121%

  • Other Info:

    Quantitative assay of antithrombin III as part of a thrombophilia screen.

    Quantitative assay of antithrombin III as part of a thrombophilia screen.

  • Routine Contact Name:

    Special Lab Freeman

  • Routine Telephone:

    0191 223 1780

    0191 223 1780

  • Routine Email:

    joanne.hall@nuth.nhs.uk

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology/Haemostasis Health Care Scientist

    Haematology/Haemostasis Health Care Scientist

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

All testing performed at Freeman Haematology laboratory and available during routine hours, Monday to Friday. Testing is usually performed on a weekly basis, depending on batch size availability.

Turn Around:

14 days, urgent on request.

Send To:

Department of Blood Sciences

Freeman Hospital
Freeman Road
Newcastle upon Tyne
NE7 7DN

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