Antithrombin III
Clinical Background:
Anti-Thrombin III, as its name suggests, is a natural anticoagulant. It is a glycoprotein produced in the liver that inactivates several enzymes of the coagulation system. Heparin exerts its antico...
Anti-Thrombin III, as its name suggests, is a natural anticoagulant. It is a glycoprotein produced in the liver that inactivates several enzymes of the coagulation system. Heparin exerts its anticoagulant activity by potentiating the action of AT-III up to 1000 fold. Deficiencies are associated with an increased risk of thrombosis and poor response to Heparin anticoagulation. This assay is part of the Thrombophilia screen
Test Details
-
Discipline:
Haemostasis
Haemostasis
-
Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
-
Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
-
Minimum Volume Adult:
10.8mL
10.8mL
-
Minimum Volume Paediatric:
5.2mL
5.2mL
-
Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
-
Sample Stability:
4 hrs
4 hrs
-
Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
-
Freq Analysis:
As required or weekly
As required or weekly
-
Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
-
Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
-
Reference Ranges:
88 - 121IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
88 - 121IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
-
Other Info:
Quantitative assay of antithrombin III as part of a thrombophilia screen.
Quantitative assay of antithrombin III as part of a thrombophilia screen.
-
Routine Contact Name:
RVI or Freeman Section Leaders
-
Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
-
Routine Email:
Joanne.hall8@nhs.net
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
-
Specialist Telephone:
0191 2139758
0191 2139758
-
Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net