Anti-Neutrophil Cytoplasmic Antibodies (ANCA)
Clinical Background:
ANCA is a test for Granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis and may appear as either perinuclear (P-ANCA) or cytoplasmic (C-ANCA)
ANCA is a test for Granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis and may appear as either perinuclear (P-ANCA) or cytoplasmic (C-ANCA)
Test Details
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Discipline:
Immunology
Immunology
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Specimen Container Adult:
Serum-SST
Serum-SST
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Specimen Container Paediatric:
Serum-Plain tube
Serum-Plain tube
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Minimum Volume Adult:
1 ml
1 ml
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Minimum Volume Paediatric:
0.5 ml
0.5 ml
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Special Requirement:
None
None
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Freq Analysis:
Available on request
Available on request
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Add On Test:
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address
All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address
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Quality Assurance:
UK NEQAS for Autoimmune Serology ANCA and GBM
UK NEQAS for Autoimmune Serology ANCA and GBM
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Interpretation:
90% of patients with WG will be positive for C-ANCA. P-ANCA is less specific and can be found in several forms of vasculitis. Serial monitoring of ANCA may help in the prediction of relapses.
90% of patients with WG will be positive for C-ANCA. P-ANCA is less specific and can be found in several forms of vasculitis. Serial monitoring of ANCA may help in the prediction of relapses.
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Reference Ranges:
Normal Range: Negative
Normal Range: Negative
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Other Info:
Reported as Negative or a titration value for Positive samples.
Reported as Negative or a titration value for Positive samples.
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Routine Contact Name:
Autoimmunity Lab
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Routine Telephone:
0191 282 1890
0191 282 1890
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Routine Email: