Newcastle Laboratories

Anti-CRMP5 Antibodies

Clinical Background:

Antibodies recognize the collapsin response-mediator brain protein (CRMP) family; CRMP5 is the dominant antigen. Associated with small cell lung cancer (SCLC) in 77% and thymoma in 6%.The syndrome ...

Antibodies recognize the collapsin response-mediator brain protein (CRMP) family; CRMP5 is the dominant antigen. Associated with small cell lung cancer (SCLC) in 77% and thymoma in 6%.The syndrome can include: subacaute sensory neuropathy; limbic encephalopathy; cereballar ataxia; extra-pyramidal syndromes; myopathy. The presence of antibodies to CV2/CRMP5 in SCLC is associated with better prognosis than anti-Hu antibodies.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    1 ml

    1 ml

  • Minimum Volume Paediatric:

    0.5 ml

    0.5 ml

  • Special Requirement:

    None

    None

  • Add On Test:

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    or

    tnu-tr.bloodsciencesadditions@nhs...

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    or

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Interpretation:

    None

    None

  • Reference Ranges:

    Normal Range: Negative

    Normal Range: Negative

  • Other Info:

    Reported as Negative or Positive

    Reported as Negative or Positive

  • Routine Contact Name:

    Jonathan Wake
  • Routine Telephone:

    0191 282 1890

    0191 282 1890

  • Routine Email:

    jonathan.wake@nuth.nhs.uk

Availability:

Sent to an external laboratory for testing.

Turn Around:

28 calendar days

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