Amino Acids (full analysis), CSF
Clinical Background:
Analysis of amino acids in CSF is performed for the investigation of a metabolic cause of intractable seizures or other severe neurological disease. The profile includes glycine (required for diag...
Analysis of amino acids in CSF is performed for the investigation of a metabolic cause of intractable seizures or other severe neurological disease. The profile includes glycine (required for diagnosis of non-ketotic hyperglycinaemia) and serine (for diagnosis of serine synthesis disorders). A paired plasma sample should be taken for comparison of CSF amino acid results with those in plasma.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
CSF in universal tube
CSF in universal tube
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Specimen Container Paediatric:
CSF in universal tube
CSF in universal tube
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Minimum Volume Adult:
0.5 mL CSF
0.5 mL CSF
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Minimum Volume Paediatric:
0.5 mL CSF
0.5 mL CSF
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Special Requirement:
Send with a paired plasma sample
Send with a paired plasma sample
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Sample Stability:
4 hours at ambient temperature
Frozen 6 months
4 hours at ambient temperature
Frozen 6 months
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Transport Requirements:
Ward: send to laboratory at ambient temperature
External laboratories: send frozen to RVI
Ward: send to laboratory at ambient temperature
External laboratories: send frozen to RVI
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Quality Assurance:
ERNDIM
ERNDIM
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Interpretation:
Ratios of CSF:plasma amino acids are reported where appropriate.
Contamination of the CSF sample with traces of blood will cause falsely elevated concentrations of amino acids.
Some drugs (e.g. val...
Read MoreRatios of CSF:plasma amino acids are reported where appropriate.
Contamination of the CSF sample with traces of blood will cause falsely elevated concentrations of amino acids.
Some drugs (e.g. valproate) can cause increased CSF amino acids.
Results will be interpreted in context of the clinical information and results of other laboratory investigations. It is therefore essential that clinical details are supplied with requests, including current medication.
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Reference Ranges:
Age-related reference ranges and interpretation provided on laboratory report
Age-related reference ranges and interpretation provided on laboratory report
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719
Freeman: 0191 244 8889
RVI: 0191 282 9719
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Routine Email:
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Metabolic Clinical Scientist
Metabolic Clinical Scientist
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Specialist Telephone:
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
0191 282 9685 (Consultant Clinical Scientist)
0191 282 0334 (Metabolic Laboratory)
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Specialist Email: