Newcastle Laboratories

Alpha 2 Antiplasmin

Clinical Background:

Alpha 2 antiplasmin (or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin (an important enzyme in the Fibrinolytic system). As plasmin is generated to degrade b...

Alpha 2 antiplasmin (or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin (an important enzyme in the Fibrinolytic system). As plasmin is generated to degrade blood clots, impaired inhibition leads to a bleeding tendency which was severe in the rare congenital cases reported. In liver cirrhosis there is decreased production of A2A, leading to decreased inactivation of plasmin and an increase in Fibrinolysis, which is associated with an increased risk of bleeding in liver disease

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    2.7mL

    2.7mL

  • Minimum Volume Paediatric:

    1.3mL

    1.3mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    2 hrs

    2 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    Fortnightly

    Fortnightly

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs....

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Quality Assurance:

    No current scheme available

    No current scheme available

  • Reference Ranges:

    80 - 120%

    80 - 120%

  • Other Info:

    Quantitative assay of alpha-2-antiplasmin (inactivates plasmin).

    Quantitative assay of alpha-2-antiplasmin (inactivates plasmin).

  • Routine Contact Name:

    Peter Strong

  • Routine Telephone:

    0191 282 0332

    0191 282 0332

  • Routine Email:

    peter.strong@nuth.nhs.uk

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology/Haemostasis Health care Scientist

    Haematology/Haemostasis Health care Scientist

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

All testing performed at RVI Haematology laboratory and available during routine hours, Monday to Friday. Testing is usually performed on a weekly basis, depending on batch size availability.

Turn Around:

4 weeks, urgent on request

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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