Alpha 2 Antiplasmin
Clinical Background:
Alpha 2 antiplasmin (or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin (an important enzyme in the Fibrinolytic system). As plasmin is generated to degrade b...
Alpha 2 antiplasmin (or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin (an important enzyme in the Fibrinolytic system). As plasmin is generated to degrade blood clots, impaired inhibition leads to a bleeding tendency which was severe in the rare congenital cases reported. In liver cirrhosis there is decreased production of A2A, leading to decreased inactivation of plasmin and an increase in Fibrinolysis, which is associated with an increased risk of bleeding in liver disease
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
2.7mL
2.7mL
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Minimum Volume Paediatric:
1.3mL
1.3mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
2 hrs
2 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
Fortnightly
Fortnightly
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Add On Test:
All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address
tnu-tr.bloodsciencesadditions@nhs.net (internal)
Read MoreAll urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address
tnu-tr.bloodsciencesadditions@nhs.net (internal)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
No current scheme available
No current scheme available
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Reference Ranges:
98 - 122%
98 - 122%
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Other Info:
Quantitative assay of alpha-2-antiplasmin (inactivates plasmin).
Quantitative assay of alpha-2-antiplasmin (inactivates plasmin).
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Routine Contact Name:
Peter Strong
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Routine Telephone:
0191 282 0332
0191 282 0332
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Routine Email:
p.strong@nhs.net
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology/Haemostasis Health care Scientist
Haematology/Haemostasis Health care Scientist
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Specialist Telephone:
0191 213 9758
0191 213 9758