Alpha 2 Antiplasmin
Clinical Background:
Alpha 2 antiplasmin (or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin (an important enzyme in the Fibrinolytic system). As plasmin is generated to degrade b...
Alpha 2 antiplasmin (or plasmin inhibitor) is a serine protease inhibitor responsible for inactivating plasmin (an important enzyme in the Fibrinolytic system). As plasmin is generated to degrade blood clots, impaired inhibition leads to a bleeding tendency which was severe in the rare congenital cases reported. In liver cirrhosis there is decreased production of A2A, leading to decreased inactivation of plasmin and an increase in Fibrinolysis, which is associated with an increased risk of bleeding in liver disease
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
2.7mL
2.7mL
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Minimum Volume Paediatric:
1.3mL
1.3mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
2 hrs
2 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
Fortnightly
Fortnightly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
No current scheme available
No current scheme available
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Reference Ranges:
98 - 122%
98 - 122%
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Other Info:
Quantitative assay of alpha-2-antiplasmin (inactivates plasmin).
Quantitative assay of alpha-2-antiplasmin (inactivates plasmin).
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net