Test Details

• Discipline:

  Biochemistry

  Biochemistry

• Specimen Container Adult:

  Serum (SST or plain tube)

  Serum (SST or plain tube)

• Specimen Container Paediatric:

  Serum (SST or plain tube)

  Serum (SST or plain tube)

• Minimum Volume Adult:

  0.5 mL

  0.5 mL

• Minimum Volume Paediatric:

  0.5 mL

  0.5 mL

• Special Requirement:

  Fasting sample required.

  Fasting sample required.

• Sample Stability:

  Unseparate sample: 4 days
  Separated sample: 7 days at 15-25C, 7 days at 2-8C, 2 months at -20C

  Unseparate sample: 4 days
  Separated sample: 7 days at 15-25C, 7 days at 2-8C, 2 months at -20C

• Interpretation:

  The liver isoenzyme is the most frequently elevated. A wide group of associated liver conditions can lead to increases in the liver isoenzyme, e.g. viral hepatitis, cirrhosis, drug induced liver di...

  The liver isoenzyme is the most frequently elevated. A wide group of associated liver conditions can lead to increases in the liver isoenzyme, e.g. viral hepatitis, cirrhosis, drug induced liver disease. It is also increased in malignancies with hepatic metastases, in cancer of the lungs and digestive tract and in lymphoma.
  
  Biliary isoenzyme (L2) (also called fast liver or macrohepatic) is associated with fragments of cell membranes derived from cells lining the biliary tract or from aggregation in bile or plasma of liver ALP with lipid or protein, e.g. PBC. Increases may occur in cholestasis and biliary diseases (e.g., cirrhosis, viral hepatitis) and in malignancies with liver metastases.
  
  Bone isoenzyme is elevated as a consequence of increased osteoblastic activity. Increased values are present in growing children and in adults over 50 years. Increased levels are found in Paget's, rickets, osteomalacia and bone cancer. Renal disorders can also result in increased bone isoenzyme levels.
  
  Intestinal isoenzyme(s) is increased in a variety of diseases of the digestive tract. This isoenzyme may also be increased with diabetes, chronic renal failure and cirrhosis of the liver, and in subjects with blood group 0 or B.
  
  Placental isoenzyme(s) is found in serum of pregnant women, late in first trimester of pregnancy. It may also occur in a small proportion of patients with cancer.
  
  Immunoglobulin complex or macro-alkaline phosphatase is a fraction that is rarely found. It remains very close to the application point on both tracks.
  
  Lipoprotein-alkaline phosphatase complex also remains very close to the application point on both tracks. It may be found in biliary obstructive diseases.
  
  Isoenzymes with atypical migrations, such as Nago, Regan and Kasahara, are difficult to identify.

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• Reference Ranges:

  Non-numeric result. Interpretative provided on report.

  Non-numeric result. Interpretative provided on report.

• Routine Contact Name:

  Duty Biochemist

• Routine Telephone:

  Freeman: 0191 244 8889
  RVI: 0191 282 9719

  Freeman: 0191 244 8889
  RVI: 0191 282 9719

• Routine Email:

  nuth.dutybiochemist@nhs.net