Newcastle Laboratories

Albumin, urine

Clinical Background:

Microalbuminuria is defined as an albumin excretion rate of 20 to 200 mg/min, and is equivalent to 30 to 300 mg/24hours (3 to 30 mg/mmol creatinine).

Microalbuminaemia has been shown to predict the...

Microalbuminuria is defined as an albumin excretion rate of 20 to 200 mg/min, and is equivalent to 30 to 300 mg/24hours (3 to 30 mg/mmol creatinine).

Microalbuminaemia has been shown to predict the later development of established clinical diabetic nephropathy in insulin dependent diabetics and of diabetic nephropathy and increased mortality in non-insulin dependent patients.

The rate of progressive deterioration of renal function may be slowed, stabilised or even reversed with improved glucose control by means of multiple injections or infusion pumps, hypertension treatment and dietary protein restriction. Early intervention (i.e. before development of clinical proteinuria) appears to be much more effective.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Plain universal tube (random collection) or 24-hour urine container

    Plain universal tube (random collection) or 24-hour urine container

  • Specimen Container Paediatric:

    Plain universal tube

    Plain universal tube

  • Minimum Volume Adult:

    6 µL (+100 µL dead volume)

    6 µL (+100 µL dead volume)

  • Minimum Volume Paediatric:

    6 µL (+100 µL dead volume)

    6 µL (+100 µL dead volume)

  • Special Requirement:

    Ideal sample required is the second void urine sample.

    Ideal sample required is the second void urine sample.

  • Sample Stability:

    7 days at 15-25C

    1 month at 2-8C


    7 days at 15-25C

    1 month at 2-8C


  • Quality Assurance:

    WEQAS

    WEQAS

  • Reference Ranges:

    Microalbumin:Creatinine Ratio:

    0 - 3 mg/mmol creatinine

     

     

    Microalbumin:Creatinine Ratio:

    0 - 3 mg/mmol creatinine

     

     

  • Factors Affecting Result:

    Erect posture and acute diuresis increase urinary albumin production.

    False positive results can be caused by contamination with menstrual or seminal fluid, or by a urinary tract infection.

    High ur...

    Erect posture and acute diuresis increase urinary albumin production.

    False positive results can be caused by contamination with menstrual or seminal fluid, or by a urinary tract infection.

    High urine volumes in poorly controlled diabetic patients may cause false negative albumin results.

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  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

Availability:

All times
All sites

Turn Around:

Urgent: within 1 hour

Non-urgent: within 1 day

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