Newcastle Laboratories

ADAMTS13

Clinical Background:

ADAMTS13 is a serine protease which controls the eventual size of the vW multimer that is in the circulation. Deficiencies of ADAMTS13 leads to Ultra Large vWM (UL-VWM) circulating in the bloodstre...

ADAMTS13 is a serine protease which controls the eventual size of the vW multimer that is in the circulation. Deficiencies of ADAMTS13 leads to Ultra Large vWM (UL-VWM) circulating in the bloodstream, the size of these molecules mean that they can cross-link non activated platelets and generate spontaneous thromboses. This can lead to Thrombotic Thrombocytopenic Purpura (TTP) which is a disorder with a potential high mortality. Deficiencies in ADAMTS13 may be congenital (Upshaw Schulman syndrome), which gives a recurring form, or acquired due to formation of auto-antibodies which give an acute disease.

For requests please use form below.

Read More

Test Documents

Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue -sodium citrate

    Light blue -sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    2.7 ml

    2.7 ml

  • Minimum Volume Paediatric:

    1.3 ml

    1.3 ml

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    2 citrated blood samples to arrive in the Blood Sciences laboratory at Freeman Hospital within 48 hrs of sample collection as uncentrifuged whole blood stored at room temperature. 

    OR

    Double spin c...

    2 citrated blood samples to arrive in the Blood Sciences laboratory at Freeman Hospital within 48 hrs of sample collection as uncentrifuged whole blood stored at room temperature. 

    OR

    Double spin citrated plasma at 2000G and separate into 4 aliquots.

    Freeze immediately at -70°C. and send frozen on dry ice.

    Note: We will not be able to test frozen samples which are defrosted on arrival

    Read More
  • Transport Requirements:

    Please telephone the laboratory before sending samples

    Samples should be transported to lab without delay

    Please telephone the laboratory before sending samples

    Samples should be transported to lab without delay

  • Freq Analysis:

    On request

    On request

  • Add On Test:

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs....

    All urgent add ons via telephone on 0191 28 24718, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

    Read More
  • Quality Assurance:

    UKNEQAS

    UKNEQAS

  • Reference Ranges:

    40 – 130 IU/dL

    40 – 130 IU/dL

  • Routine Contact Name:

    Special Lab Freeman

  • Routine Telephone:

    0191 223 1780

    0191 223 1780

  • Routine Email:

    joanne.hall@nuth.nhs.uk

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology/Haemostasis Health Care Scientist

    Haematology/Haemostasis Health Care Scientist

  • Specialist Telephone:

    0191 213 9758

    0191 213 9758

Availability:

Routine hours, Monday to Friday (this is 4 hour ELISA assay and may need to be performed during the next working day depending on time sample received)

View all tests