Newcastle Laboratories

ADAMTS13 IgG Inhibitor

Clinical Background:

Severe deficiency of ADAMTS13 activity leading TTP may be due to an acquired IgG Inhibitor of ADAMTS13.

The inhibitor may develop secondary to a clinical condition or therapy, or may be idiopathic....

Severe deficiency of ADAMTS13 activity leading TTP may be due to an acquired IgG Inhibitor of ADAMTS13.

The inhibitor may develop secondary to a clinical condition or therapy, or may be idiopathic.

The use of and ELISA ADAMTS13 IgG inhibitor assay may distinguish between congenital and acquired deficiencies. It may also be used to monitor the response to therapy for Acute TTP

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue -sodium citrate

    Light blue -sodium citrate

  • Specimen Container Paediatric:

    Light blue -sodium citrate

    Light blue -sodium citrate

  • Minimum Volume Adult:

    2.7 ml

    2.7 ml

  • Minimum Volume Paediatric:

    1.3 ml

    1.3 ml

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    2 citrated blood samples to arrive in the Blood Sciences laboratory at the RVI within 48 hrs of sample collection as centrifuged whole blood stored at room temperature.

    OR

    Double spun citrated plas...

    2 citrated blood samples to arrive in the Blood Sciences laboratory at the RVI within 48 hrs of sample collection as centrifuged whole blood stored at room temperature.

    OR

    Double spun citrated plasma at 2000G and separate into 4 aliquots. Freeze immediately at < -70°C. and sent frozen on dry ice.

    Note: We will not be able to test frozen samples which are defrosted on arrival

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  • Transport Requirements:

    Please telephone the laboratory before sending samples. Samples should be transported to lab without delay

    Please telephone the laboratory before sending samples. Samples should be transported to lab without delay

  • Freq Analysis:

    On request

    On request

  • Add On Test:

  • Quality Assurance:

    UKNEQAS

    UKNEQAS

  • Reference Ranges:

    Negative              <12 U/mL

    Borderline           12 – 15 U/mL

    Positive               >15 U/mL

    ...

    Negative              <12 U/mL

    Borderline           12 – 15 U/mL

    Positive               >15 U/mL

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  • Routine Contact Name:

    RVI or Freeman Section Leaders

  • Routine Telephone:

    RVI: 0191 2820332, Freeman: 0191 2231195

    RVI: 0191 2820332, Freeman: 0191 2231195

  • Routine Email:

    paul.murphy4@nhs.net

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology and Haemostasis Healthcare Scientist

    Haematology and Haemostasis Healthcare Scientist

  • Specialist Telephone:

    0191 2139758

    0191 2139758

  • Specialist Email:

    alison.brown93@nhs.net

    alison.brown93@nhs.net

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