ADAMTS13 IgG Inhibitor

Clinical Background:

Severe deficiency of ADAMTS13 activity leading TTP may be due to an acquired IgG Inhibitor of ADAMTS13.

The inhibitor may develop secondary to a clinical condition or therapy, or may be idiopathic....

Severe deficiency of ADAMTS13 activity leading TTP may be due to an acquired IgG Inhibitor of ADAMTS13.

The inhibitor may develop secondary to a clinical condition or therapy, or may be idiopathic.

The use of and ELISA ADAMTS13 IgG inhibitor assay may distinguish between congenital and acquired deficiencies. It may also be used to monitor the response to therapy for Acute TTP

Discipline:

Haemostasis

Haemostasis
Specimen Container Adult:

Light blue -sodium citrate

Light blue -sodium citrate
Specimen Container Paediatric:

Light blue -sodium citrate

Light blue -sodium citrate
Minimum Volume Adult:

2.7 ml

2.7 ml
Minimum Volume Paediatric:

1.3 ml

1.3 ml
Special Requirement:

Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Sample Stability:

2 citrated blood samples to arrive in the Blood Sciences laboratory at the RVI within 48 hrs of sample collection as centrifuged whole blood stored at room temperature.

OR

Double spun citrated plas...

2 citrated blood samples to arrive in the Blood Sciences laboratory at the RVI within 48 hrs of sample collection as centrifuged whole blood stored at room temperature.

OR

Double spun citrated plasma at 2000G and separate into 4 aliquots. Freeze immediately at < -70°C. and sent frozen on dry ice.

Note: We will not be able to test frozen samples which are defrosted on arrival
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Transport Requirements:

Please telephone the laboratory before sending samples. Samples should be transported to lab without delay

Please telephone the laboratory before sending samples. Samples should be transported to lab without delay
Freq Analysis:

On request

On request
Add On Test:

tnu-tr.bloodsciencesadditions@nhs.net (external)

tnu-tr.bloodsciencesadditions@nhs.net (external)
Quality Assurance:

UKNEQAS

UKNEQAS
Reference Ranges:

Negative              <12 U/mL

Borderline           12 – 15 U/mL

Positive >15 U/mL
...

Negative              <12 U/mL

Borderline           12 – 15 U/mL

Positive >15 U/mL
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Routine Contact Name:

RVI or Freeman Section Leaders
Routine Telephone:

RVI: 0191 2820332, Freeman: 0191 2231195

RVI: 0191 2820332, Freeman: 0191 2231195
Routine Email:

paul.murphy4@nhs.net
Specialist Test:

Yes

Yes
Specialist Contact Name:

Haematology and Haemostasis Healthcare Scientist

Haematology and Haemostasis Healthcare Scientist
Specialist Telephone:

0191 2139758

0191 2139758
Specialist Email:

alison.brown93@nhs.net

alison.brown93@nhs.net

ADAMTS13 IgG Inhibitor

Clinical Background:

Test Details