Topiramate
Clinical Background:
Topiramate is a very effective drug in the treatment of simple and complex partial seizures with and without generalization. It is also effective against myoclonic jerks. Topiramate is partly metab...
Topiramate is a very effective drug in the treatment of simple and complex partial seizures with and without generalization. It is also effective against myoclonic jerks. Topiramate is partly metabolised in the liver, partly excreted unchanged in the urine. The half-life is 20-30hours. Nevertheless it is most often administered twice a day. When administered together with inducing drugs the half-life falls to 15 hours. The drug is to some extent excreted in an unchanged form via the kidneys. In the case of elderly people, who perhaps have a reduced kidney function, a smaller dose should be given to avoid side effects. Topiramate has many side effects, such as dizziness, fatigue, ataxia, paraesthesia, confusion, abnormal thinking, agitation, amnesia, aphasia, depression, diplopia, nausea, anorexia, weight loss and kidney stones.
Test Details
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Discipline:
Biochemistry
Biochemistry
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Specimen Container Adult:
0.5 mL
0.5 mL
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Specimen Container Paediatric:
0.5 mL
0.5 mL
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Minimum Volume Adult:
2 mL
2 mL
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Minimum Volume Paediatric:
1 mL
1 mL
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Reference Ranges:
5-20 mg/L
5-20 mg/L
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Routine Contact Name:
Duty Biochemist
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Routine Telephone:
Freeman: 0191 244 8889
RVI: 0191 282 9719Freeman: 0191 244 8889
RVI: 0191 282 9719 -
Routine Email: