Thrombophilia Screen
Clinical Background:
This is a set panel of tests performed on individuals to determine if they have any of the alterations in the Haemostatic system known to be associated with an increased risk of thrombosis. The ful...
This is a set panel of tests performed on individuals to determine if they have any of the alterations in the Haemostatic system known to be associated with an increased risk of thrombosis. The full thrombophilia screen consists of a clotting screen, Protein C and S assays, Antithrombin-III assay, APCR, DRVV Ratio, Anticardiolipin assays and a pcr for the Factor II mutation that is associated with increased thrombotic risk, a PCR for factor V Leiden will also be performed on samples with a positive APCR. Requests for Thrombophilia screening are reviewed by a Consultant Haematologist before testing to ensure the appropriate tests are performed in line with current BSH guidelines, meaning that the full panel is not always performed on every request.
Test Details
-
Discipline:
Haemostasis
Haemostasis
-
Specimen Container Adult:
Light blue - sodium citrate x 2 + Yellow/Red serum
Light blue - sodium citrate x 2 + Yellow/Red serum
-
Specimen Container Paediatric:
Light blue - sodium citrate x 2 + Yellow/Red serum
Light blue - sodium citrate x 2 + Yellow/Red serum
-
Minimum Volume Adult:
10.8mL
10.8mL
-
Minimum Volume Paediatric:
5.2mL
5.2mL
-
Special Requirement:
Citrate samples must be filled correctly to the line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Citrate samples must be filled correctly to the line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
-
Sample Stability:
See individual tests
See individual tests
-
Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
-
Freq Analysis:
As required or weekly
As required or weekly
-
Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
-
Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
-
Interpretation:
-
Reference Ranges:
See specific tests.
See specific tests.
-
Other Info:
Full thrombophilia screen consisting of:
Coagulation Screen
Protein S (free)
Protein C (functional)
Antithrombin III
APC Resistance Ratio
Lupus anticoagulant
Anticardiolipin Antibodies
Factor II Mu...
Read MoreFull thrombophilia screen consisting of:
Coagulation Screen
Protein S (free)
Protein C (functional)
Antithrombin III
APC Resistance Ratio
Lupus anticoagulant
Anticardiolipin Antibodies
Factor II Mutation
Factor V Leiden Mutation (If suggested by APC Ratio)
-
Routine Contact Name:
RVI or Freeman Section Leaders
-
Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
-
Specialist Telephone:
0191 2139758
0191 2139758
-
Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net