Newcastle Laboratories

Serum Electrophoresis

Clinical Background:

Guidelines for the Interpretation and Management of immunoglobulins and Paraproteins in Adults.pdf

 

Serum electrophoresis is carried out on all immunoglobulin requests to determine if immunoglobul...

Guidelines for the Interpretation and Management of immunoglobulins and Paraproteins in Adults.pdf

 

Serum electrophoresis is carried out on all immunoglobulin requests to determine if immunoglobulins present are polyclonal or monoclonal. Monoclonal proteins are associated with lymphoid malignancies including myeloma. If a monoclonal protein is identified by electrophoresis its immunotype will be investigated by immunofixation. If large enough it will be measured by densitometry. If identified discussion with a haematologist is advised as per guideline attached.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum

    Serum

  • Specimen Container Paediatric:

    Serum

    Serum

  • Special Requirement:

    None

    None

  • Sample Stability:

    10 days at 2-8oC
    3 months at -20oC

    10 days at 2-8oC
    3 months at -20oC

  • Freq Analysis:

    Daily

    Daily

  • Add On Test:

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net 

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    tnu-tr.bloodsciencesadditions@nhs.net 

  • Quality Assurance:

    UK NEQAS for MONOCLONAL PROTEIN IDENTIFICATION

    IMMPROVE paraprotein quality assurance

     

    UK NEQAS for MONOCLONAL PROTEIN IDENTIFICATION

    IMMPROVE paraprotein quality assurance

     

  • Interpretation:

    See guideline above

    See guideline above

  • Reference Ranges:

    not applicable

    not applicable

  • Other Info:

    All requests for Immunoglobulins (Igs) are examined by serum electrophoresis. If a paraprotein band is detected it is quantitated by scanning densitometry and a result given in g/L. Further investi...

    All requests for Immunoglobulins (Igs) are examined by serum electrophoresis. If a paraprotein band is detected it is quantitated by scanning densitometry and a result given in g/L. Further investigations will define the nature of the paraprotein (see immunofixation). If the serum electrophoresis is normal it will be reported as such.

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  • Routine Contact Name:

    Proteins Lab

  • Routine Telephone:

    0191 282 4766

    0191 282 4766

  • Routine Email:

Availability:

Serum Protein Electrophoresis assays are run several times a day Monday to Friday 08:30 to 17:00.

Turn Around:

3 routine working days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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