Newcastle Laboratories

Ristocetin Co-factor

Clinical Background:

The 'gold standard' for assessing von Willebrand Factor functional activity. Normal Ristocetin Co-Factor activity requires a normal level of full length plasma von Willebrand Multimers. The assay i...

The 'gold standard' for assessing von Willebrand Factor functional activity. Normal Ristocetin Co-Factor activity requires a normal level of full length plasma von Willebrand Multimers. The assay is especially important in determining the response of type 2 vWD patients to treatment, vW Antigen may rise in type 2 patients without a rise in function, with the potential for bleeding problems if only the antigen was used to determine response.

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    5.4mL

    5.4mL

  • Minimum Volume Paediatric:

    2.6mL

    2.6mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    4 hrs

    4 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    As required or weekly

    As required or weekly

  • Add On Test:

  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    40 - 150%

     

    Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see

    https://www.newcastlelaboratories.com/lab_service/core-247/

    for details.

    40 - 150%

     

    Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see

    https://www.newcastlelaboratories.com/lab_service/core-247/

    for details.

  • Other Info:

    Used in the diagnosis of von Willebrand Disease.

    Performed as part of a vW Screen.

    Used in the diagnosis of von Willebrand Disease.

    Performed as part of a vW Screen.

  • Routine Contact Name:

    RVI or Freeman Section Leaders

  • Routine Telephone:

    RVI: 0191 2820332, Freeman: 0191 2231195

    RVI: 0191 2820332, Freeman: 0191 2231195

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology and Haemostasis Healthcare Scientist

    Haematology and Haemostasis Healthcare Scientist

  • Specialist Telephone:

    0191 2139758

    0191 2139758

  • Specialist Email:

    alison.brown93@nhs.net

    alison.brown93@nhs.net

Availability:

All testing performed at RVI Haematology laboratory and available during routine hours, Monday to Friday. Testing is usually performed on a weekly basis, depending on batch size availability.

Turn Around:

Usually within 7 days.

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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