Protein S
Clinical Background:
Protein S is one of the natural anticoagulants. It is a vitamin dependant plasma glycoprotein and is a co-factor to Protein C in the inactivation of Factors Va and VIIIa. Deficiencies in Protein S ...
Protein S is one of the natural anticoagulants. It is a vitamin dependant plasma glycoprotein and is a co-factor to Protein C in the inactivation of Factors Va and VIIIa. Deficiencies in Protein S lead to an increased thrombotic risk. Protein S levels fall phsyioloigcally during pregancy. It is assayed as part of the Thrombophilia Screen
Test Details
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Discipline:
Haemostasis
Haemostasis
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Specimen Container Adult:
Light blue - sodium citrate
Light blue - sodium citrate
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Specimen Container Paediatric:
Light blue - sodium citrate
Light blue - sodium citrate
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Minimum Volume Adult:
10.8mL
10.8mL
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Minimum Volume Paediatric:
5.2mL
5.2mL
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Special Requirement:
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.
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Sample Stability:
4 hrs
4 hrs
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Transport Requirements:
Samples should be transported to lab without delay
Samples should be transported to lab without delay
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Freq Analysis:
Weekly
Weekly
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Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Quality Assurance:
UK NEQAS Blood Coagulation
UK NEQAS Blood Coagulation
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Reference Ranges:
Male 75 - 142IU/dL
Female 65 - 136IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
Read MoreMale 75 - 142IU/dL
Female 65 - 136IU/dL
Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see
https://www.newcastlelaboratories.com/lab_service/core-247/
for details.
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Other Info:
Quantitative assay of free protein S performed as part of a thrombophilia screen.
Quantitative assay of free protein S performed as part of a thrombophilia screen.
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Routine Contact Name:
RVI or Freeman Section Leaders
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Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
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Routine Email:
Joanne.hall8@nhs.net
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Specialist Test:
Yes
Yes
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Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
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Specialist Telephone:
0191 2139758
0191 2139758
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Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net