Newcastle Laboratories

Protein C

Clinical Background:

Protein C is one of the natural anticoagulants. It is a vitamin dependant plasma glycoprotein and binds to thrombomodulin with Protein S as a co-factor to inactivate Factors Va and VIIIa. Deficienc...

Protein C is one of the natural anticoagulants. It is a vitamin dependant plasma glycoprotein and binds to thrombomodulin with Protein S as a co-factor to inactivate Factors Va and VIIIa. Deficiencies in Protein C lead to an increased thrombotic risk. It is assayed as part of the Thrombophilia Screen

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Test Details

  • Discipline:

    Haemostasis

    Haemostasis

  • Specimen Container Adult:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Specimen Container Paediatric:

    Light blue - sodium citrate

    Light blue - sodium citrate

  • Minimum Volume Adult:

    10.8mL

    10.8mL

  • Minimum Volume Paediatric:

    5.2mL

    5.2mL

  • Special Requirement:

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

    Tube must be correctly filled to line, to ensure correct ratio of blood to anticoagulant, ensure adequate mixing.

  • Sample Stability:

    4 hrs

    4 hrs

  • Transport Requirements:

    Samples should be transported to lab without delay

    Samples should be transported to lab without delay

  • Freq Analysis:

    Weekly

    Weekly

  • Add On Test:

  • Quality Assurance:

    UK NEQAS Blood Coagulation

    UK NEQAS Blood Coagulation

  • Reference Ranges:

    79 - 150IU/dL

     

    Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see

    https://www.newcastlelaboratories.com/lab_service/core-247/

    for details.

    79 - 150IU/dL

     

    Note: For Haemostatic tests, paediatric reference ranges may be different to adult ranges. Please see

    https://www.newcastlelaboratories.com/lab_service/core-247/

    for details.

  • Other Info:

    Quantitative assay of functional protein C as part of a thrombophilia screen.

    Quantitative assay of functional protein C as part of a thrombophilia screen.

  • Routine Contact Name:

    RVI or Freeman Section Leaders

  • Routine Telephone:

    RVI: 0191 2820332, Freeman: 0191 2231195

    RVI: 0191 2820332, Freeman: 0191 2231195

  • Routine Email:

    Joanne.hall8@nhs.net

  • Specialist Test:

    Yes

    Yes

  • Specialist Contact Name:

    Haematology and Haemostasis Healthcare Scientist

    Haematology and Haemostasis Healthcare Scientist

  • Specialist Telephone:

    0191 2139758

    0191 2139758

  • Specialist Email:

    alison.brown93@nhs.net

    alison.brown93@nhs.net

Availability:

All testing performed at Freeman Haematology laboratory and available during routine hours, Monday to Friday. Testing is usually performed on a weekly basis, depending on batch size availability.

Turn Around:

14 days, urgent on request

Send To:

Department of Blood Sciences

Freeman Hospital
Freeman Road
Newcastle upon Tyne
NE7 7DN

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