Newcastle Laboratories

Immunoglobulin E

Clinical Background:

Total IgE is sometimes measured in the investigation of allergy, however the normal range is very wide and levels correlate poorly with clinical disease. Very high levels of IgE are seen in atopic ...

Total IgE is sometimes measured in the investigation of allergy, however the normal range is very wide and levels correlate poorly with clinical disease. Very high levels of IgE are seen in atopic eczema, asthma, parasitic infections, lymphoma and liver disease. IgE myeloma is very rare.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Specimen Container Paediatric:

    Serum (SST or plain tube)

    Serum (SST or plain tube)

  • Minimum Volume Adult:

    1 ml

    1 ml

  • Minimum Volume Paediatric:

    0.5 mL

    0.5 mL

  • Sample Stability:

    Unseparated sample: unknown
    Separate sample: 7 days at 15-25C, 7 days at 2-8C, 6 months at -20C

    6 months at -20C

    Unseparated sample: unknown
    Separate sample: 7 days at 15-25C, 7 days at 2-8C, 6 months at -20C

    6 months at -20C

  • Freq Analysis:

    Daily

    Daily

  • Add On Test:

    All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address

    nuth.autoimmunity@nhs.net

     

    All urgent add ons via telephone on 0191 2821890, and must be confirmed via email to the appropriate email address

    nuth.autoimmunity@nhs.net

     

  • Quality Assurance:

    UK NEQAS for Total IgE

    UK NEQAS for Total IgE

  • Interpretation:

    IgE myeloma is very rare. A high specific IgE to a single allergen (see RAST testing) may occur with a total IgE in the normal range.

    IgE myeloma is very rare. A high specific IgE to a single allergen (see RAST testing) may occur with a total IgE in the normal range.

  • Reference Ranges:

    Age Range                          Total IgE Level (IU/L)

    Neonates:                                      0-1.5     

    Infants in 1st year of life:              0-15  

    Children aged 1-5 years:        ...

    Age Range                          Total IgE Level (IU/L)

    Neonates:                                      0-1.5     

    Infants in 1st year of life:              0-15  

    Children aged 1-5 years:            0-60     

    Children aged 6-9 years:            0-90     

    Children aged 10-15 years:       0-200   

    Adults:                                            0-100   

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  • Other Info:

    A high specific IgE to a single allergen (see RAST testing) may occur with a total IgE in the normal range.

    A high specific IgE to a single allergen (see RAST testing) may occur with a total IgE in the normal range.

  • Routine Contact Name:

    Autoimmunity Lab

  • Routine Telephone:

    0191 282 1890

    0191 282 1890

  • Routine Email:

  • Specialist Email:

    nuth.autoimmunity@nhs.net

    nuth.autoimmunity@nhs.net

Availability:

Total IgE samples are tested on a daily basis, Monday to Friday 08:30 to 17:00.

Turn Around:

3 routine working days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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