IGHV analysis
Clinical Background:
The mutational profile of the IGHV gene is prognostic in CLL. The outcome of patients with leukaemia cells that use an unmutated IGHV gene (usually defined as 98% or more sequence homology to the n...
The mutational profile of the IGHV gene is prognostic in CLL. The outcome of patients with leukaemia cells that use an unmutated IGHV gene (usually defined as 98% or more sequence homology to the nearest germ line gene) is inferior to that of patients with leukaemia cells that use a mutated IGHV gene.
Test Details
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Discipline:
NEHODS
NEHODS
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Specimen Container Adult:
EDTA
EDTA
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Specimen Container Paediatric:
EDTA
EDTA
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Minimum Volume Adult:
5 mL
5 mL
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Minimum Volume Paediatric:
5 mL
5 mL
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Special Requirement:
Please complete NEHODS request form
Please complete NEHODS request form
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Sample Stability:
N/A
N/A
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Transport Requirements:
Samples should be sent to laboratory immediately.
Samples should be sent to laboratory immediately.
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Freq Analysis:
N/A
N/A
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Add On Test:
Can be added to any genetics sample where DNA has been stored
Can be added to any genetics sample where DNA has been stored
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Quality Assurance:
Leeds
Leeds
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Interpretation:
By genetics clinical scientist
By genetics clinical scientist
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Reference Ranges:
N/A
N/A
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Factors Affecting Result:
Quality and size of sample
Quality and size of sample
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Referenced Documents:
N/A
N/A
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Other Info:
Testing done with HMDS, Leeds
Testing done with HMDS, Leeds