G6PD Deficiency Screen
Clinical Background:
G6PD is an enzyme that protects red blood cells from oxidative damage. Without it they are vunerable to haemolysis. Triggers for damage can include anti-malarial medication and antibiotics. G6PD...
G6PD is an enzyme that protects red blood cells from oxidative damage. Without it they are vunerable to haemolysis. Triggers for damage can include anti-malarial medication and antibiotics. G6PD deficiency can also cause prolonged jaundice in newborns. The gene is on the X Chromosome and so the disorder affects more males than females. Females with one faulty X chromosome can usually produce enough enzyme to avoid symptoms, given an equivocal result on the screening test
Test Details
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Discipline:
Protein Lab
Protein Lab
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Specimen Container Adult:
Purple - EDTA
Purple - EDTA
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Specimen Container Paediatric:
Purple - EDTA
Purple - EDTA
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Minimum Volume Adult:
0.5mL
0.5mL
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Minimum Volume Paediatric:
0.5mL
0.5mL
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Special Requirement:
Ensure adequate mixing.
Ensure adequate mixing.
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Sample Stability:
7 days stored between 2-26oC
7 days stored between 2-26oC
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Add On Test:
All urgent add ons via telephone must be confirmed via email to the appropriate email address
tnu-tr.bloodsciencesadditions@nhs.net (internal)
tnu-tr.bloodsciencesadditions@nhs.net (external)
All urgent add ons via telephone must be confirmed via email to the appropriate email address
tnu-tr.bloodsciencesadditions@nhs.net (internal)
tnu-tr.bloodsciencesadditions@nhs.net (external)
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Interpretation:
Suspected equivocal or deficient cases will have a quantitative assay performed by Kings College Hospital in London.
Suspected equivocal or deficient cases will have a quantitative assay performed by Kings College Hospital in London.
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Reference Ranges:
G6PD screen- Not applicable- Results = Normal, Equivocal or Deficient
Quantitative assay completed by Kings College London: 6.6-13.8 IU/g Hb
G6PD screen- Not applicable- Results = Normal, Equivocal or Deficient
Quantitative assay completed by Kings College London: 6.6-13.8 IU/g Hb
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Other Info:
Samples should be sent with FBC for interpretation
Samples should be sent with FBC for interpretation
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Routine Contact Name:
Proteins Lab
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Routine Telephone:
0191 282 4766
0191 282 4766
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Routine Email:
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Specialist Test:
Yes
Yes