Factor V Leiden Mutation

Clinical Background:

Factor V Leiden is a variant form of human factor V that is associated with an increased risk of thrombosis. Due to the mutation, in which arginine is replaced with glutamine, activated protein C i...

Factor V Leiden is a variant form of human factor V that is associated with an increased risk of thrombosis. Due to the mutation, in which arginine is replaced with glutamine, activated protein C is unable to bind normally to activated factor V and downregulate the prothrombotic action, resulting in an increased thrombotic tendency.

Factor V Leiden is the most common hereditary hypercoagulability disorder amongst ethnic Europeans

Discipline:

Haemostasis

Haemostasis
Specimen Container Adult:

Light blue- sodium citrate

Light blue- sodium citrate
Specimen Container Paediatric:

Light blue – sodium citrate (semi-transparent cap)

Light blue – sodium citrate (semi-transparent cap)
Minimum Volume Adult:

Single whole blood sample

Single whole blood sample
Minimum Volume Paediatric:

Single whole blood sample

Single whole blood sample
Sample Stability:

7 days @4°C

7 days @4°C
Transport Requirements:

Samples should be transported to the laboratory without delay

Samples should be transported to the laboratory without delay
Freq Analysis:

Fortnightly or urgent as required

Fortnightly or urgent as required
Add On Test:

tnu-tr.bloodsciencesadditions@nhs.net (external)

tnu-tr.bloodsciencesadditions@nhs.net (external)
Quality Assurance:

UK NEQAS Blood Coagulation

UK NEQAS Blood Coagulation
Reference Ranges:

Prevalence in general population                                             5%

Prevalence in patients presenting with DVT or PE             30%
...

Prevalence in general population                                             5%

Prevalence in patients presenting with DVT or PE             30%
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Other Info:

Thrombotic risk

Heterozygote                                                    4 to 8 fold increase

Homozygote                                                      40 – 80 fold increase

Increase...

Thrombotic risk

Heterozygote                                                    4 to 8 fold increase

Homozygote                                                      40 – 80 fold increase

Increased risk of thrombosis in pregnancy

Increased risk with Oestrogen containing oral contraception

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Routine Contact Name:

RVI or Freeman Section Leaders
Routine Telephone:

RVI: 0191 2820332, Freeman: 0191 2231195

RVI: 0191 2820332, Freeman: 0191 2231195
Specialist Test:

Yes

Yes
Specialist Contact Name:

Haematology and Haemostasis Healthcare Scientist

Haematology and Haemostasis Healthcare Scientist
Specialist Telephone:

0191 2139758

0191 2139758
Specialist Email:

alison.brown93@nhs.net

alison.brown93@nhs.net

Factor V Leiden Mutation

Clinical Background:

Test Details