Erythropoietin
Clinical Background:
Erythropoietin is a glycoprotein hormone that controls erythropoiesis (red cell production). It is produced by interstitial fibroblasts in the kidneys and also perisiusoidla cells in the liver. EPO...
Erythropoietin is a glycoprotein hormone that controls erythropoiesis (red cell production). It is produced by interstitial fibroblasts in the kidneys and also perisiusoidla cells in the liver. EPO also plays a role in the brain's response to neuronal injury and is also involved in the wound healing process. Production is regulated by changes in Oxygen availability. An over expression may be seen in COPD, cyanotic heart disease, sleep apnoea, smoking, or due to over production by neoplastic cells. Elevated EPO is also found in aplastic anaemia, iron deficiency, thalassaemia, megaloblastic anaemia and myelodysplasia. Low EPO production is found in conjunction with certain forms of anaemic states such as renal failure, auto-immune disease, rheumatoid arthritis, AIDS and malnutrition
Test Details
-
Discipline:
Haematology - Specials
Haematology - Specials
-
Specimen Container Adult:
Purple - EDTA
Purple - EDTA
-
Specimen Container Paediatric:
Purple - EDTA
Purple - EDTA
-
Minimum Volume Adult:
2.0mL
2.0mL
-
Minimum Volume Paediatric:
1.0mL
1.0mL
-
Special Requirement:
Ensure adequate mixing.
Ensure adequate mixing.
-
Sample Stability:
Centrifuge within 30 mins of collection. Seperated plasma is stable in fridge for 7 days or indefinitely in the freezer.
Centrifuge within 30 mins of collection. Seperated plasma is stable in fridge for 7 days or indefinitely in the freezer.
-
Transport Requirements:
Sample must be transported to lab without delay (see sample stability information)
Sample must be transported to lab without delay (see sample stability information)
-
Freq Analysis:
Approximately weekly depending on batch size
Approximately weekly depending on batch size
-
Add On Test:
tnu-tr.bloodsciencesadditions@nhs.net (external)
tnu-tr.bloodsciencesadditions@nhs.net (external)
-
Quality Assurance:
UK NEQAS
UK NEQAS
-
Reference Ranges:
4.2 - 16.3mIU/mL
4.2 - 16.3mIU/mL
-
Other Info:
Quantitative assay for erythropoietin levels.
Quantitative assay for erythropoietin levels.
-
Routine Contact Name:
RVI or Freeman Section Leaders
-
Routine Telephone:
RVI: 0191 2820332, Freeman: 0191 2231195
RVI: 0191 2820332, Freeman: 0191 2231195
-
Routine Email:
Joanne.hall8@nhs.net
-
Specialist Test:
Yes
Yes
-
Specialist Contact Name:
Haematology and Haemostasis Healthcare Scientist
Haematology and Haemostasis Healthcare Scientist
-
Specialist Telephone:
0191 2139758
0191 2139758
-
Specialist Email:
alison.brown93@nhs.net
alison.brown93@nhs.net