COVID-19 antibody screen
Clinical Background:
SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) is the strain of coronavirus that causes COVID-19.
Two different assays are available for testing.
SARS-CoV-2 antibody
Detects total antibo...
SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) is the strain of coronavirus that causes COVID-19.
Two different assays are available for testing.
SARS-CoV-2 antibody
Detects total antibody to nucleocapsid protein
Will detect antibody response to past SARS-CoV-2 infection. Will NOT detect antibody response to SARS-CoV-2 vaccination.
Suggested use: Testing for evidence of prior SARS-CoV-2 infection is clinically indicated (where no PCR result is available), e.g PIMS-TS.
SARS-CoV-2 S1/S2 IgG
Detects IgG class antibody to spike protein
Will detect antibody response to past SARS-CoV-2 infection. Will also detect antibody response to SARS-CoV-2 vaccination.
Suggested use: When considering monoclonal antibodies for the treatment of COVID-19 in admitted patients. Testing of post-vaccination response is NOT recommended.
It should be noted that not everyone will develop detectable antibodies after infection.
Samples received for testing will be tested using the SARS CoV-s S1/S2 IgG unless specifically requested otherwise.
Test Details
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Discipline:
Serology
Serology
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Specimen Container Adult:
Clotted blood - Gold SST
Clotted blood - Gold SST
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Specimen Container Paediatric:
Clotted blood
Clotted blood
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Minimum Volume Adult:
1ml
1ml
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Minimum Volume Paediatric:
1ml
1ml
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Special Requirement:
Send to laboratory as quickly as possible. If delays likely, refrigerate at 2 - 8 °C
Send to laboratory as quickly as possible. If delays likely, refrigerate at 2 - 8 °C
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Sample Stability:
Stable for up to 24 hours
Stable for up to 24 hours
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Transport Requirements:
Standard
Standard
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Add On Test:
N/A
N/A
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Quality Assurance:
UKNEQAS
UKNEQAS
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Factors Affecting Result:
If delays likely, refrigerate at 2 - 8 °C
If delays likely, refrigerate at 2 - 8 °C