Newcastle Laboratories

CGD proteins

Clinical Background:

Chronic Granulomatous Disease (CGD) is a primary immunodeficiency of defective neutrophil oxidative burst activity. It is caused by defects of NADPH oxidase, the enzyme responsible for the producti...

Chronic Granulomatous Disease (CGD) is a primary immunodeficiency of defective neutrophil oxidative burst activity. It is caused by defects of NADPH oxidase, the enzyme responsible for the production of reactive oxygen species needed to kill pathogenic bacteria and fungi. NADPH oxidase has a membrane-bound flavocytochrome b558, which is comprised of gp91phox and p22phox and cytosolic components comprised of p40phox, p47phox and p67phox. Assays for gp91, p22, p47 and p67phox provide additional diagnostic information for CGD following initial abnormal testing by oxidative burst and NBT

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Test Details

  • Discipline:

    Flow Cytometry

    Flow Cytometry

  • Specimen Container Adult:

    Purple top EDTA

    Purple top EDTA

  • Specimen Container Paediatric:

    pink top paediatric EDTA

    pink top paediatric EDTA

  • Minimum Volume Adult:

    4 mL

    4 mL

  • Minimum Volume Paediatric:

    2 mL

    2 mL

  • Sample Stability:

    48 hours

    48 hours

  • Transport Requirements:

    Ambient

    Ambient

  • Freq Analysis:

    As required

    As required

  • Add On Test:

    not possible 

    not possible 

  • Reference Ranges:

     All CGD proteins should be normally expressed.

     All CGD proteins should be normally expressed.

  • Routine Contact Name:

    Flow Cytometry Lab

  • Routine Telephone:

    0191 282 5078

    0191 282 5078

  • Routine Email:

Availability:

Only available by prior arrangement with the laboratory (ext 25078) and discussion with a clinical immunologist (paediatric or adult)

Turn Around:

2 working days

Send To:

Department of Blood Sciences
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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