Newcastle Laboratories

C3-nephritic factor

Clinical Background:

C3 Nephritic factors are autoantibodies which enhances C3 activation. C3 Nephritic factors are found in more than 80% of patients with Dense Deposit Disease (DDD) and 40-50% of patients with C3-glo...

C3 Nephritic factors are autoantibodies which enhances C3 activation. C3 Nephritic factors are found in more than 80% of patients with Dense Deposit Disease (DDD) and 40-50% of patients with C3-glomerulonephritis (C3-GN). C3 Nephritic Factors can also be detected in some individuals with partial lipodystrophy, pancreatitis, macular degeneration and rarely in asymptomatic individuals.

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Test Details

  • Discipline:

    Immunology

    Immunology

  • Specimen Container Adult:

    Serum-SST

    Serum-SST

  • Specimen Container Paediatric:

    Serum-Plain tube

    Serum-Plain tube

  • Minimum Volume Adult:

    2 ml

    2 ml

  • Minimum Volume Paediatric:

    2 ml

    2 ml

  • Special Requirement:

    Samples MUST be separated within 4 hours of venesection. Please ensure that the sample arrives in the laboratory as soon as possible after being taken.

    Samples MUST be separated within 4 hours of venesection. Please ensure that the sample arrives in the laboratory as soon as possible after being taken.

  • Sample Stability:

    1 year at -80 degrees. Samples should not be freeze thawed prior to testing

    1 year at -80 degrees. Samples should not be freeze thawed prior to testing

  • Freq Analysis:

    Fortnightly

    Fortnightly

  • Add On Test:

    Can only be added by discussion with Proteins Laboratory 

    Can only be added by discussion with Proteins Laboratory 

  • Quality Assurance:

    The lab participates in a Sample Exchange with Sheffield 

    The lab participates in a Sample Exchange with Sheffield 

  • Interpretation:

    None

    None

  • Reference Ranges:

    Not Applicable

    Not Applicable

  • Other Info:

    Reported as Present or Absent.

    All C3 Neph requests are considered, we no longer reject samples based on a normal total C3. If total C3 is within the normal range patient serum is separated by elec...

    Reported as Present or Absent.

    All C3 Neph requests are considered, we no longer reject samples based on a normal total C3. If total C3 is within the normal range patient serum is separated by electrophoresis and investigated for evidence of C3 breakdown.
    If no evidence of breakdown is seen then further testing for C3 nephritic factor is not indicated. If there is evidence of C3 breakdown the further investigation will be carried out.

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  • Routine Contact Name:

    Proteins Lab

  • Routine Telephone:

    0191 282 4766

    0191 282 4766

  • Routine Email:

Availability:

The C3-nephritic Factor assay is performed only as required, Monday to Friday 08:30 to 17:00

Turn Around:

21 calendar days

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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