Newcastle Laboratories

Anti-TNF alpha biologicals

Clinical Background:

The measurement of anti-TNF alpha biologicals is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring ...

The measurement of anti-TNF alpha biologicals is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring drug levels allows for a personalised approach to drug optimisation by appropriate dose escalation/de-escalation or drug switching/withdrawal.

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Test Documents

Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

  • Specimen Container Paediatric:

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

     

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

     

  • Minimum Volume Adult:

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

  • Minimum Volume Paediatric:

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

  • Special Requirement:

    Ideally take sample just before drug administration (trough level)

    The referral laboratory request form should accompany the sample. 

    Ideally take sample just before drug administration (trough level)

    The referral laboratory request form should accompany the sample. 

  • Sample Stability:

    Keep in fridge until transport.

    If transport is going to be delayed by > 5 days, freeze at -20°C

    Keep in fridge until transport.

    If transport is going to be delayed by > 5 days, freeze at -20°C

  • Transport Requirements:

    First class post at ambient temperature

    First class post at ambient temperature

  • Other Info:

    Analysis will include BOTH drug and anti-drug antibody analysis

    Analysis will include BOTH drug and anti-drug antibody analysis

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

Availability:

Sample sent to an external laboratory for testing

Turn Around:

4 weeks

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