Newcastle Laboratories

Alpha1-antitrypsin phenotyping, serum

Clinical Background:

Used to identify homozygous and heterozygous phenotypes of A1AT deficiency.

Used to identify homozygous and heterozygous phenotypes of A1AT deficiency.

Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum

    Serum

  • Specimen Container Paediatric:

    Serum 

    Serum 

  • Minimum Volume Adult:

    2 mL blood

    2 mL blood

  • Minimum Volume Paediatric:

    2 mL blood

    2 mL blood

  • Special Requirement:

    Store sample at 4°C

    Store sample at 4°C

  • Transport Requirements:

    Post at room temperature

    Post at room temperature

  • Reference Ranges:

    There are over 40 A1AT phenotypes, with most associated with normal quantitative levels of protein. Most normal individuals have the M phenotype with over 99% of M phenotypes being genetically MM. ...

    There are over 40 A1AT phenotypes, with most associated with normal quantitative levels of protein. Most normal individuals have the M phenotype with over 99% of M phenotypes being genetically MM. The most common alleles associated with a quantitative deficiency are Z and S with the majority being ZZ.

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  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

Availability:

Sample sent to an external laboratory for analysis

Turn Around:

< 7 days

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