Newcastle Laboratories

Alpha1-antitrypsin, faecal

Clinical Background:

Inflammatory bowel disease can lead to a protein-losing enteropathy resulting in increased loss of plasma proteins into the gut. Alpha-1 antitrypsin is protein which is relatively resistant to brea...

Inflammatory bowel disease can lead to a protein-losing enteropathy resulting in increased loss of plasma proteins into the gut. Alpha-1 antitrypsin is protein which is relatively resistant to breakdown by proteolytic enzymes found in the gut and may pass relatively unchanged into the faeces. Levels of alpha-1 antitrypsin in faeces may be used as a guide to the extent of protein loss into the gut, although some studies have shown a high frequency of false negative results. Nevertheless, a positive finding may be useful in confirming a diagnosis of protein-losing enteropathy and monitoring progress of the disease. A negative result does not exclude protein-losing enteropathy.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Faeces sample

    Faeces sample

  • Specimen Container Paediatric:

    Faeces sample

    Faeces sample

  • Minimum Volume Adult:

    10g faeces

    10g faeces

  • Minimum Volume Paediatric:

    10g faeces

    10g faeces

  • Special Requirement:

    Ward: send to the laboratory at ambient temperature

    External laboratories: send frozen to the laboratory

    Ward: send to the laboratory at ambient temperature

    External laboratories: send frozen to the laboratory

  • Transport Requirements:

    Must be transported on dry ice and sent early in the week

    Must be transported on dry ice and sent early in the week

  • Reference Ranges:

    0 - 0.48 mg/g wet weight      

    (0.35 - 0.48 mg/g is borderline)

    0 - 0.48 mg/g wet weight      

    (0.35 - 0.48 mg/g is borderline)

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

Availability:

Sample sent to an external laboratory for analysis

Turn Around:

5 weeks

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