Newcastle Laboratories

Alpha1-acid glycoprotein, serum

Clinical Background:

For research study ONLY

It is a "slow" acute phase reactant. Serum levels are increased in inflammation, tissue necrosis and malignancy. Reduced serum levels are seen during pregnancy and as a resu...

For research study ONLY

It is a "slow" acute phase reactant. Serum levels are increased in inflammation, tissue necrosis and malignancy. Reduced serum levels are seen during pregnancy and as a result of treatment with exogenous oestrogens. It is of little use in the assessment of the acute phase response though it may be useful as a marker of activity in IBD.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum

    Serum

  • Specimen Container Paediatric:

    Serum

    Serum

  • Minimum Volume Adult:

    0.5 mL

    0.5 mL

  • Minimum Volume Paediatric:

    0.5 mL

    0.5 mL

  • Special Requirement:

    Store sample at 4°C

    Store sample at 4°C

  • Transport Requirements:

    Post at room temperature

    Post at room temperature

  • Interpretation:

    A1AG is a 40kDa glycoprotein. It is a 'slow' acute phase reactant. Serum levels are increased in inflammation, tissue necrosis and malignancy. Reduced serum levels are seen during pregnancy and as ...

    A1AG is a 40kDa glycoprotein. It is a 'slow' acute phase reactant. Serum levels are increased in inflammation, tissue necrosis and malignancy. Reduced serum levels are seen during pregnancy and as a result of treatment with exogenous oestrogens. It is of little use in the assessment of the acute phase response though it may be useful as a marker of activity in IBD.

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  • Reference Ranges:

    Paediatric

    <1y: 0.4 - 1.0 g/L

    Male

    1 - 50y: 0.6 - 1.2 g/L

    50+ y: 0.8 - 2.0 g/L

    Female

    1 - 50y: 0.4 - 1.0 g/L

    50+ y: 0.8 - 2.0 g/L

    Paediatric

    <1y: 0.4 - 1.0 g/L

    Male

    1 - 50y: 0.6 - 1.2 g/L

    50+ y: 0.8 - 2.0 g/L

    Female

    1 - 50y: 0.4 - 1.0 g/L

    50+ y: 0.8 - 2.0 g/L

  • Factors Affecting Result:

    Very lipaemic or tubid samples, Haemolysis. EDTA, citrate, and oxalate anticoagulants.

    Very lipaemic or tubid samples, Haemolysis. EDTA, citrate, and oxalate anticoagulants.

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

Availability:

Sample sent to an external laboratory for analysis

Turn Around:

5 days

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