Newcastle Laboratories

Alkaline phosphatase, serum

Clinical Background:

Alkaline phosphatases are a group of enzymes which hydrolyse phosphates at an alkaline pH. They are found in bone, liver, kidney, intestinal wall, lactating mammary glands and placenta.

Alkaline phosphatases are a group of enzymes which hydrolyse phosphates at an alkaline pH. They are found in bone, liver, kidney, intestinal wall, lactating mammary glands and placenta.

Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum sample

    Serum sample

  • Specimen Container Paediatric:

    Serum sample

    Serum sample

  • Minimum Volume Adult:

    1 mL blood

    1 mL blood

  • Minimum Volume Paediatric:

    0.5 mL blood

    0.5 mL blood

  • Sample Stability:

    Unseparated sample: 4 days

    Separated sample:

    - 7 days at 15-25C

    - 7 days at 4ºC

    - 2 months at -20C

    Unseparated sample: 4 days

    Separated sample:

    - 7 days at 15-25C

    - 7 days at 4ºC

    - 2 months at -20C

  • Add On Test:

    Add-on available up to 7 days

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-...

    Add-on available up to 7 days

    All urgent add ons via telephone on 0191 282 4766, and must be confirmed via email to the appropriate email address

    RVIadditions.Laboratory@nuth.nhs.uk (internal)

    tnu-tr.bloodsciencesadditions@nhs.net (external)

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  • Interpretation:

    CAUSES OF RAISED ALKALINE PHOSPHATASE
    1. Physiological
    a) Children until the age of puberty.
    b) Pregnancy in the last trimester.
    2. Bone disease
    a) Osteomalacia and rickets
    b) Primary hyperparath...

    CAUSES OF RAISED ALKALINE PHOSPHATASE
    1. Physiological
    a) Children until the age of puberty.
    b) Pregnancy in the last trimester.
    2. Bone disease
    a) Osteomalacia and rickets
    b) Primary hyperparathyroidism with bone disease.
    c) Paget's disease.
    d) Secondary carcinoma in bone.
    e) Some cases of osteogenic sarcoma.
    3. Liver disease
    a) Cholestasis
    b) Hepatitis
    c) Cirrhosis of liver (sometimes).
    d) Space occupying lesions - tumours, granulomata, infiltrations.
    4. Induction by drugs such as barbiturates.

    CAUSES OF LOW ALKALINE PHOSPHATASE
    1. Arrested bone growth : Achondroplasia, Cretinism, Vitamin C deficiency.
    2. Hypophosphatasia.

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  • Reference Ranges:

    Male:

    Up to 14 days:                    83 – 248 IU/L

    Up to 1 year:                      122 – 469 IU/L

    Up to 10 years:                  142 – 335 IU/L

    Up to 13 years:                  129 – 417 IU...

    Male:

    Up to 14 days:                    83 – 248 IU/L

    Up to 1 year:                      122 – 469 IU/L

    Up to 10 years:                  142 – 335 IU/L

    Up to 13 years:                  129 – 417 IU/L

    Up to 15 years:                 116 – 468 IU/L

    Up to 17 years:                   82 – 331 IU/L

    Up to 18 years:                    40 – 250 IU/L

    18 years and over:             30 – 130 IU/L

     

    Female:

    Up to 14 days:                    83 – 248 IU/L

    Up to 1 year:                      122 – 469 IU/L

    Up to 10 years:                  142 – 335 IU/L

    Up to 13 years:                  129 – 417 IU/L

    Up to 15 years:                   57 – 254 IU/L

    Up to 17 years:                   50 – 117 IU/L

    17 years and over:             30 – 130 IU/L

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  • Factors Affecting Result:

    Do not use EDTA or fluoride plasma.
    Haemolysis
    In very rare cases gammopathy, in particular type IgM (Waldenström’s macroglobulinemia), may cause unreliable results.

    Do not use EDTA or fluoride plasma.
    Haemolysis
    In very rare cases gammopathy, in particular type IgM (Waldenström’s macroglobulinemia), may cause unreliable results.

  • Other Info:

    Plasma- Lithium Heparin also acceptable

    Plasma- Lithium Heparin also acceptable

  • Routine Contact Name:

    Duty Biochemist

  • Routine Telephone:

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

    Freeman: 0191 244 8889
    RVI: 0191 282 9719

  • Routine Email:

    - For external users: TNU-Tr.duty.biochemist@nhs.net

    - For Trust users: DutyBiochemist@nuth.nhs.uk

Availability:

All times

All sites

Turn Around:

Urgent: within 1 hour

Non-urgent: within 4 hours

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