Newcastle Laboratories

Adalimumab

Clinical Background:

The measurement of anti-TNF alpha biologicals is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring ...

The measurement of anti-TNF alpha biologicals is a useful tool in managing patients who fail to respond (primary failure) or who go on to lose response (secondary failure) to treatment. Monitoring drug levels allows for a personalised approach to drug optimisation by appropriate dose escalation/de-escalation or drug switching/withdrawal.

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Test Details

  • Discipline:

    Biochemistry

    Biochemistry

  • Specimen Container Adult:

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

  • Specimen Container Paediatric:

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

     

    Serum or plasma. Collect blood into a serum separation (SST), plain or lithium heparin tube

     

  • Minimum Volume Adult:

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

  • Minimum Volume Paediatric:

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

    Minimum 300 μL serum or plasma required for both drug and anti-drug antibody analysis

  • Special Requirement:

    Ideally take sample just before drug administration (trough level)

     

    Ideally take sample just before drug administration (trough level)

     

  • Sample Stability:

    Keep in fridge until transport.

    If transport is going to be delayed by > 5 days, freeze at -20°C

    Keep in fridge until transport.

    If transport is going to be delayed by > 5 days, freeze at -20°C

  • Transport Requirements:

    First class post at ambient temperature

    First class post at ambient temperature

  • Other Info:

    Analysis will include BOTH drug and anti-drug antibody analysis

    Analysis will include BOTH drug and anti-drug antibody analysis

  • Routine Contact Name:

    Autoimmunity Lab

  • Routine Telephone:

    0191 282 1890

    0191 282 1890

  • Routine Email:

    tnu-tr.Immunology@nhs.net

Send To:

Department of Blood Sciences

Level 3
Leazes Wing
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
NE1 4LP

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